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Phospholipid metabolism
Synthesis, remodeling, transport and degradation of glycerophospholipids. 218 reactions, from Reactome R-HSA-1483257.
- 2-acyl LPC is acylated to PC by LPCAT2-acyl LPC + acyl-CoA → PC + CoA-SH
- 1-acyl LPG is acylated to PG by LPGAT1-acyl LPG + acyl-CoA → PG + CoA-SH
- 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL2-MAG + H2O → Glycerol + fatty acid
- 2-acyl LPE is hydrolyzed to GPETA by PLA2G4C2-acyl LPE + H2O → GPETA + LCFA(-)
- 2-acyl LPG is acylated to PG by CRLS1 (IM)2-acyl LPG + acyl-CoA → PG + CoA-SH
- 1-acyl LPC is acylated to PC by LPCAT1-acyl LPC + acyl-CoA → PC + CoA-SH
- 1-acyl LPA is acylated to PA by AGPAT5 (OM)1-acyl LPA + acyl-CoA → PA + CoA-SH
- 1-acyl LPE is hydrolyzed to GPETA by PLA2G4C1-acyl LPE + H2O → GPETA + LCFA(-)
- 1-acyl LPI is acylated to PI by MBOAT71-acyl LPI + acyl-CoA → PI + CoA-SH
- PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)PA + H2O → 1-acyl LPA + LCFA(-)
- 2-acyl LPC is hydrolyzed to GPCho by PLA2[8]2-acyl LPC + H2O → GPCho + LCFA(-)
- 2-acyl LPI is acylated to PI by MBOAT72-acyl LPI + acyl-CoA → PI + CoA-SH
- 2-acyl LPC is hydrolyzed to GPCho by PLA2G4C2-acyl LPC + H2O → GPCho + LCFA(-)
- 2-acyl LPG is acylated to PG by LPGAT2-acyl LPG + acyl-CoA → PG + CoA-SH
- 1-acyl LPS is acylated to PS by LPSAT1-acyl LPS + acyl-CoA → PS + CoA-SH
- 2-acyl LPE is acylated to PE by LPEAT2-acyl LPE + acyl-CoA → PE + CoA-SH
- 2-MAG and DAG are transacylated to TAG by PNPLA2/32-MAG + DAG → TAG + Glycerol
- 2-MAG is transacylated to DAG by PNPLA2/32 2-MAG → DAG + Glycerol
- PA is hydrolysed to 1-acyl LPA by PLA2[1]PA + H2O → 1-acyl LPA + LCFA(-)
- 1-acyl LPE is acylated to PE by LPEAT1-acyl LPE + acyl-CoA → PE + CoA-SH
- PA is hydrolysed to 1-acyl LPA by PLA2G2APA + H2O → 1-acyl LPA + LCFA(-)
- 1-acyl LPC is hydrolyzed to GPCho by PLA2[8]1-acyl LPC + H2O → GPCho + LCFA(-)
- 1-acyl LPG is acylated to PG by CRLS1 (IM)1-acyl LPG + acyl-CoA → PG + CoA-SH
- 2-acyl LPS is acylated to PS by LPSAT2-acyl LPS + acyl-CoA → PS + CoA-SH
- G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)G3P + acyl-CoA → 1-acyl LPA + CoA-SH
- 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C1-acyl LPC + H2O → GPCho + LCFA(-)
- PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)PG + H2O → 1-acyl LPG + LCFA(-)
- MLCL is hydrolyzed to DLCL by PLA2G4A (IM)MLCL + H2O → DLCL + LCFA(-)
- PS is hydrolyzed to 1-acyl LPS by PLA2[9]PS + H2O → 1-acyl LPS + LCFA(-)
- MLCL transports from the IM to the ERMLCL → MLCL
- MLCL is acylated to CL by HADH (IM)MLCL + acyl-CoA → cardiolipin + CoA-SH
- PS is hydrolyzed to 1-acyl LPS by PLA2G2APS + H2O → 1-acyl LPS + LCFA(-)
- TAG is hydrolyzed to DAG by PNPLA2/3TAG + H2O → DAG + LCFA(-)
- CL is hydrolyzed to MLCL by PLA2G6 (IM)cardiolipin + H2O → MLCL + LCFA(-)
- MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)MLCL + PC → cardiolipin + 1-acyl LPC
- CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)cardiolipin + 1-acyl LPC → MLCL + PC
- DAG is hydrolyzed to 2-MAG by PNPLA2/3DAG + H2O → 2-MAG + LCFA(-)
- PC is hydrolyzed to 1-acyl LPC by PLA2[6]PC + H2O → 1-acyl LPC + LCFA(-)
- PI is hydrolyzed to 1-acyl LPI by PLA2[11]PI + H2O → 1-acyl LPI + LCFA(-)
- PC is hydrolyzed to 2-acyl LPC by PLA2G4CPC + H2O → 2-acyl LPC + LCFA(-)
- PE is hydrolyzed to 2-acyl LPE by PLA2[4]PE + H2O → 2-acyl LPE + LCFA(-)
- PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)PG + H2O → 2-acyl LPG + LCFA(-)
- MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)MLCL + PE → cardiolipin + 1-acyl LPE
- PC is hydrolyzed to 1-acyl LPC by PLA2[5]PC + H2O → 1-acyl LPC + LCFA(-)
- CL transports from the ER to the IMCL → cardiolipin
- DLCL transports from the IM to the ERDLCL → DLCL
- MLCL is acylated to CL by LCLAT1 (ER)MLCL + acyl-CoA → CL + CoA-SH
- PC is hydrolysed to 2-acyl LPC by PLA2[7]PC + H2O → 2-acyl LPC + LCFA(-)
- DLCL is acylated to MLCL by LCLAT1 (ER)DLCL + acyl-CoA → MLCL + CoA-SH
- PI is hydrolyzed to 1-acyl LPI by PLA2[12]PI + H2O → 1-acyl LPI + LCFA(-)
- PE is hydrolyzed to 1-acyl LPE by PLA2[2]PE + H2O → 1-acyl LPE + LCFA(-)
- PE is hydrolyzed to 1-acyl LPE by PLA2[3]PE + H2O → 1-acyl LPE + LCFA(-)
- DAG is acylated to TAG by DGAT1/2DAG + acyl-CoA → TAG + CoA-SH
- PE is hydrolyzed to 2-acyl LPE by PLA2G4CPE + H2O → 2-acyl LPE + LCFA(-)
- CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)cardiolipin + 1-acyl LPE → MLCL + PE
- PS is hydrolyzed to 2-acyl LPS by PLA2[10]PS + H2O → 2-acyl LPS + LCFA(-)
- PG is hydrolyzed to 1-acyl LPG by PLA2[1]PG + H2O → 1-acyl LPG + LCFA(-)
- PG is hydrolyzed to 1-acyl LPG by PLA2G2APG + H2O → 1-acyl LPG + LCFA(-)
- PG is hydrolyzed to 2-acyl LPG by PLA2[14]PG + H2O → 2-acyl LPG + LCFA(-)
- PI is hydrolyzed to 2-acyl LPI by PLA2[13]PI + H2O → 2-acyl LPI + LCFA(-)
- CDP-DAG is converted to PGP by PGS1CDP-DAG + G3P → PGP + CMP
- CDP-Cho and DAG are converted to PC by CEPT1 at the ER membraneDAG + CDP-Cho → PC + CMP
- CDP-ETA and DAG are converted to PE by CEPT1/EPT1DAG + CDP-ETA → PE + CMP
- CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membraneCDP-Cho + DAG → CMP + PC
- CDP-DAG is converted to PI by CDIPTCDP-DAG + Ins → PI + CMP
- DHAP is converted to 1-acyl GO3P by GNPATDHAP + acyl-CoA → CoA-SH + GO3P
- Cho is phosphorylated to PCho by CHK dimerCho + ATP → PCho + ADP
- PG and CDP-DAG are converted to CL by CRLS1PG + CDP-DAG → cardiolipin + CMP
- PE transports from the mitochondrial membrane to the ERPE → PE
- PCho and CTP are condensed to CDP-Cho by PCYT1 dimerPCho + CTP → CDP-Cho + PPi
- PI is exchanged with PC by PITPNBPI:PITPNB + PC → PI + PC:PITPNB
- PE is converted to PS by PTDSS2PE + L-Ser → PS + ETA
- PETA is dephosphorylated to ETA by PHOSPHO1PETA + H2O → ETA + Pi
- PA translocates from the outer to the inner mitochondrial membranePA → PA
- GPETA is hydrolyzed to ETA and G3P by GPCPD1GPETA + H2O → ETA + G3P
- GPCho is hydrolyzed to Cho and G3P by GPCPD1GPCho + H2O → Cho + G3P
- PA is converted to CDP-DAG by CDS1PA + CTP → CDP-DAG + PPi
- PC is transphosphatidylated to PG by PLD1-4/6PC + Glycerol → PG + Cho
- PCho is dephosphorylated to Cho by PHOSPHO1PCho + H2O → Cho + Pi
- PA is converted to CDP-DAG by CDS2PA + CTP → CDP-DAG + PPi
- PS transports from the ER membrane to the IM membranePS → PS
- PE is methylated to PC by PEMTPE + 3 AdoMet → PC + 3 AdoHcy
- PC is hydrolyzed to PA and choline by PLD1/2PC + H2O → PA + Cho
- PC is converted to PS by PTDSS1PC + L-Ser → PS + Cho
- PETA and CTP are condensed to CDP-ETA by PCY2PETA + CTP → CDP-ETA + PPi
- PTPMT1 dephosphorylates PGP to PGH2O + PGP → PG + Pi
- PA is dephosphorylated to DAG by LPINPA + H2O → DAG + Pi
- PG is converted to BMPPG → BMP
- PC:PITPNB is transported from the Golgi membrane to the ER membranePC:PITPNB → PC:PITPNB
- PS is decarboxylated to PE by PISDPS → PE + CO2
- PG transports from the ER membrane to the late endosome membranePG → PG
- PC is exchanged with PI by PITPNBPC:PITPNB + PI → PI:PITPNB + PC
- ETA is phosphorylated to PETA by CHK/ETNKETA + ATP → PETA + ADP
- PI:PITPNB is transported from the ER membrane to the Golgi membranePI:PITPNB → PI:PITPNB
- PG is hydrolyzed to 1-acyl LPG by PLA2[16]PG + H2O → 1-acyl LPG + LCFA(-)
- PS is hydrolyzed to 1-acyl LPS by PLA2[15]PS + H2O → 1-acyl LPS + LCFA(-)
- PI is hydrolyzed to 1-acyl LPI by PLA2[15]PI + H2O → 1-acyl LPI + LCFA(-)
- PE is hydrolyzed to 1-acyl LPE by PLA2[16]PE + H2O → 1-acyl LPE + LCFA(-)
- PC is hydrolyzed to 1-acyl LPC by PLB1PC + H2O → 1-acyl LPC + LCFA(-)
- PC is hydrolyzed to 1-acyl LPC by PLA2[16]PC + H2O → 1-acyl LPC + LCFA(-)
- PA is hydrolyzed to 1-acyl LPA by PLA2[15]PA + H2O → 1-acyl LPA + LCFA(-)
- PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membranePI(3,4)P2 + ATP → PI(3,4,5)P3 + ADP
- PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membranePI5P + ATP → PI(4,5)P2 + ADP
- PI is phosphorylated to PI4P by PI4K2A/B at the plasma membranePI + ATP → PI4P + ADP
- PI3P is dephosphorylated to PI by MTM proteins at the late endosome membraneH2O + PI3P → PI + Pi
- PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membranePI + ATP → PI5P + ADP
- PI is phosphorylated to PI4P by PI4KA/2B at the ER membranePI + ATP → PI4P + ADP
- PI4P transports from the Golgi membrane to the plasma membranePI4P → PI4P
- PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membraneH2O + PI(4,5)P2 → PI4P + Pi
- PI(3,4)P2 is transported from the plasma membrane to the early endosome membranePI(3,4)P2 → PI(3,4)P2
- PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membranePI(3,5)P2 + H2O → PI3P + Pi
- PI is phosphorylated to PI5P by PIKFYVE at the late endosome membraneATP + PI → ADP + PI5P
- PI is phosphorylated to PI4P by PI4KB at the Golgi membraneATP + PI → ADP + PI4P
- PI(3,5)P2 transports from the early endosome membrane to the Golgi membranePI(3,5)P2 → PI(3,5)P2
- PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membraneATP + PI3P → ADP + PI(3,5)P2
- PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membraneATP + PI3P → ADP + PI(3,5)P2
- PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membraneATP + PI4P → ADP + PI(3,4)P2
- PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membraneATP + PI → ADP + PI3P
- PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membranePI(3,4,5)P3 + H2O → PI(3,4)P2 + Pi
- PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membraneATP + PI → ADP + PI3P
- PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membraneATP + PI → ADP + PI4P
- PI4P is dephosphorylated to PI by SYNJ at the plasma membranePI4P + H2O → PI + Pi
- PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membranePI3P + H2O → PI + Pi
- PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membraneH2O + PI(3,5)P2 → PI3P + Pi
- PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membraneH2O + PI(3,5)P2 → PI3P + Pi
- PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membraneATP + PI → ADP + PI3P
- Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosomePI(3,5)P2 → PI(3,5)P2
- PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membranePI(4,5)P2 + ATP → PI(3,4,5)P3 + ADP
- PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membraneH2O + PI(3,5)P2 → PI5P + Pi
- PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membranePI4P + ATP → PI(4,5)P2 + ADP
- PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membraneH2O + PI(3,5)P2 → PI5P + Pi
- PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membranePI4P + ATP → PI(3,4)P2 + ADP
- PI3P is dephosphorylated to PI by SACM1L at the Golgi membraneH2O + PI3P → PI + Pi
- PI4P is dephosphorylated to PI by SACM1L at the ER membranePI4P + H2O → PI + Pi
- PI4P is dephosphorylated to PI by SACM1L at the Golgi membranePI4P → PI + Pi
- PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membranePI3P + ATP → PI(3,5)P2 + ADP
- PI3P is dephosphorylated to PI by MTM proteins at the early endosome membraneH2O + PI3P → PI + Pi
- PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membranePI3P + ATP → PI(3,4)P2 + ADP
- PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membranePI(3,4)P2 + H2O → PI4P + Pi
- PI4KB binds to ARF1/3:GTP at the Golgi membraneARF1/3:GTP + PI4KB → ARF1/3:GTP:PI4KB
- PI(3,5)P2 transports from the late endosome membrane to the Golgi membranePI(3,5)P2 → PI(3,5)P2
- PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membraneH2O + PI(3,4)P2 → PI3P + Pi
- PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membranePI(3,4)P2 + H2O → PI3P + Pi
- PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membraneATP + PI3P → ADP + PI(3,5)P2
- PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membraneH2O + PI(3,5)P2 → PI3P + Pi
- PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membranePI(4,5)P2 + H2O → PI4P + Pi
- PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membraneATP + PI → ADP + PI4P
- PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membranePI(3,5)P2 + H2O → PI5P + Pi
- PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membraneH2O + PI(3,4)P2 → PI4P + Pi
- PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membraneATP + PI4P → ADP + PI(3,4)P2
- Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)G3P + FAD → DHAP + FADH2
- PTEN dephosphorylates PIP3PI(3,4,5)P3 + H2O → PI(4,5)P2 + Pi
- Cho is acetylated to AcCho by CHATAc-CoA + Cho → CoA-SH + AcCho
- AcCho is hydrolyzed to Cho and acetate by ACHEAcCho + H2O → Cho + acetate
- Cho transports from the extracellular space to the cytosolCho → Cho
- CPNEs bind PLCPNEs + PL → CPNEs:PL
- G3P is acylated to 1-acyl LPA by AGPAT6G3P + acyl-CoA → 1-acyl LPA + CoA-SH
- ABHD3 hydrolyses LPC(14:0) to 1AGPCLPC(14:0) + H2O → 1AGPC + RCOO-
- ABHD4 hydrolyses NAPENAPE + H2O → GPAEA + acyl group
- AGK:Mg2+ phosphorylates MAG, DAGMAG,DAG + ATP → LPA,PA + ADP
- PXLP-K278-ETNPPL tetramer hydrolyses PETAPETA + H2O → CH3CHO + NH3 + Pi
- AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAGMAG + Acyl-CoA → DAG + CoA-SH
- DDHD1,2 hydrolyse PAPA + H2O → 1-acyl LPA + LCFA(-)
- LIPH, I hydrolyse PA to 2-acyl LPAPA + H2O → 2-acyl LPA + LCFA(-)
- MTMR7 binds MTMR9MTMR7 + MTMR9 → MTMR7:MTMR9
- MTMR8 binds MTMR9MTMR8 + MTMR9 → MTMR8:MTMR9
- MTMR6 binds MTMR9MTMR6 + MTMR9 → MTMR6:MTMR9
- PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membranePI(3,5)P2 + H2O → PI5P + Pi
- PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membranePI3P + H2O → PI + Pi
- MTMR12 binds MTM1MTM1 + MTMR12 → MTM1:MTMR12
- MTMR12 binds MTMR2MTMR2 + MTMR12 → MTMR2:MTMR12
- PI3P is dephosphorylated to PI by MTM1:MTMR12H2O + PI3P → PI + Pi
- SBF1 binds MTMR2MTMR2 + SBF1 → MTMR2:SBF1
- PI3P is dephosphorylated to PI by MTMR2:SBF1PI3P + H2O → Pi + PI
- PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1PI(3,5)P2 + H2O → PI5P + Pi
- MTMR2 dimerizes2 MTMR2 → MTMR2 homodimer
- MTMR2 binds SBF2MTMR2 homodimer + SBF2 homodimer → MTMR2:SBF2 Tetramer
- PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membranePI(3,5)P2 + H2O → PI5P + Pi
- PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membranePI3P + H2O → PI + Pi
- MTMR2 binds MTMR10MTMR2 + MTMR10 → MTMR2:MTMR10
- TMEM55B translocates to the nucleusTMEM55B → TMEM55B
- PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleusPI(4,5)P2 + H2O → Pi + PI5P
- PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleusPI5P + ATP → ADP + PI(4,5)P2
- GDE1 hydrolyzes GroPInsGroPIns + H2O → G3P + Ins
- GDPD5 hydrolyzes GPChoGPCho + H2O → Cho + G3P
- PNPLA6 hydrolyzes LysoPtdChoLysoPtdCho + H2O → GPCho + LCFA(-)
- GDPD1 hydrolyzes LysoPtdChoLysoPtdCho + H2O → GPCho + LCFA(-)
- GDPD3 hydrolyzes LysoPtdChoLysoPtdCho + H2O → GPCho + LCFA(-)
- ENPP6 hydrolyzes lysophosphatidylcholinelysophosphatidylcholine + H2O → ChoP + MAG
- 1-acyl LPA is acylated to PA by AGPAT (LPAAT)1-acyl LPA + acyl-CoA → PA + CoA-SH
- DHAP is converted to G3P by GPD1/GPD1LDHAP + NADH + H+ → G3P + NAD+
- PNPLA7 hydrolyzes LysoPtdChoLysoPtdCho + H2O → GPCho + LCFA(-)
- DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAGDAG + acyl-CoA → TAG + CoA-SH
- PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membranePI(4,5)P2, PI(3,4)P2, PI(3,4,5)P3 + H2O → PI5P, PI3P, PI(3,5)P2 + Pi
- HRASLS transfer acyl group from PC to PE to form NAPEPC + PE → LysoPtdCho + NAPE
- MFSD2A transports LPC from extracellular region to plasma membraneLPC (22:6) + Na+ → LPC (22:6) + Na+
- OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membranePS + PI4P → PS + PI4P
- PITPNM1,2,3 exchange PI for PAPI + PA → PI + PA
- PLA1A hydrolyses PS to 2-acyl LPSH2O + PS → 2-acyl LPS + LCFA(-)
- PTPN13:PLEKHA1,2 bind PI(3,4)P2PTPN13:PLEKHA1,2 + PI(3,4)P2 → PTPN13:PLEKHA1,2:PIP2
- PLEKHA4,(5,6) bind PI3PPLEKHA4,(5,6) + PI3P → PLEKHA4,(5,6):PI3P
- PLEKHA3,8 bind PI4P, ARF1PLEKHA3,8 + PI4P + ARF1 → ARF1:PLEKHA3,8:PI4P
- p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTPp-Y389,400-RUFY1 + RAB14:GTP + RAB4A:GTP + RAB5A:GTP → p-Y389,400-RUFY1:p-Y389,400-RUFY1:RAB4A:GTP:RAB5:GTP:RAB14:GTP
- p-Y389,400-RUFY1 translocates from cytosol to early endosome membranep-Y389,400-RUFY1 → p-Y389,400-RUFY1
- BMX phosphorylates RUFY1RUFY1 + 2 ATP → p-Y389,400-RUFY1 + 2 ADP + H+
- p-Y389,400-RUFY1 binds PI3Pp-Y389,400-RUFY1 + PI3P → p-Y389,400-RUFY1:PI3P
- PCTP binds PCPCTP + PC → PCTP:PC
- STARD10 transports PC from ER membrane to lamellar body membraneSTARD10:LPCAT1:PC → STARD10:PC + LPCAT1
- STARD10 binds LPCAT1 and PCSTARD10 + LPCAT1 + PC → STARD10:LPCAT1:PC
- Casein kinase II phosphorylates STARD10STARD10 + ATP → p-S284-STARD10 + ADP
- THEM86B hydrolyses PMCHO, PMETAMPMCHO, PMETAM + H2O → fatty aldehyde + GPCHO, GPETAM
- TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membranePI(4,5)P2, PI(3,4,5)P3 → PI(4,5)P2, PI(3,4,5)P3
- ACP6 hydrolyses MYS-LPAMYS-LPA + H2O → 1-MMG + Pi
- ALPI dimer hydrolyses phosphate monoestersH2O + phosphate monoester → Pi + Alcohol
- PLA2G15 hydrolyses LPC to GPCho and LCFA(-)lysoPC + H2O → GPCho + LCFA(-)
- PLD6 dimer hydrolyses cardiolipin to PA and PGcardiolipin + H2O → PA + PG
- PGP:Mg2+ dimer hydrolyses G3P to glycerolH2O + G3P → Glycerol + Pi
- STARD7 transports PC from ER membrane to mitochondrial outer membranePC → PC