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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

2-MAG and DAG are transacylated to TAG by PNPLA2/3

2-MAG + DAG → TAG + Glycerol

Reactome: R-HSA-1482647
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

2-MAGCHEBI:17389, C4H7O4R, endoplasmic reticulum membrane
DAGCHEBI:17815, C5H6O5R2, endoplasmic reticulum membrane

Outputs

TAGCHEBI:17855, C6H5O6R3, endoplasmic reticulum membrane
GlycerolCHEBI:17754, C3H8O3, cytosol

Catalysed by

acylglycerol O-acyltransferase activity of PNPLA2/3 [endoplasmic reticulum membrane]EC 2.3.1

Literature

Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities J Biol Chem, 2004