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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
Data
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MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)

MLCL + PE → cardiolipin + 1-acyl LPE

Reactome
R-HSA-1482850
Compartment
mitochondrial inner membrane
Rhea
None recorded

Inputs

  • MLCLCHEBI:60430, C12H19O16P2R3, mitochondrial inner membrane
  • PECHEBI:57613, C7H12NO8PR2, mitochondrial inner membrane

Outputs

  • cardiolipinCHEBI:28494, C13H18O17P2R4, mitochondrial inner membrane
  • 1-acyl LPECHEBI:29017, C6H13NO7PR, mitochondrial inner membrane

Catalysed by

  • acyltransferase activity, transferring groups other than amino-acyl groups of TAZ [mitochondrial inner membrane]EC 2.3.1; UniProt Q16635

Literature

  1. Remodeling of cardiolipin by phospholipid transacylation J Biol Chem, 2003
  2. The enzymatic function of tafazzin J Biol Chem, 2006
  3. Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species Biochim Biophys Acta, 2009