CL is hydrolyzed to MLCL by PLA2G6 (IM)
cardiolipin + H2O → MLCL + LCFA(-)
- Reactome
- R-HSA-1482778
- Compartment
- mitochondrial inner membrane · mitochondrial matrix
- Rhea
- None recorded
Inputs
- cardiolipinCHEBI:28494, C13H18O17P2R4, mitochondrial inner membrane
- H2OCHEBI:15377, H2O, mitochondrial matrix
Outputs
- MLCLCHEBI:60430, C12H19O16P2R3, mitochondrial inner membrane
- LCFA(-)CHEBI:57560, CO2R, mitochondrial inner membrane
Catalysed by
- A2-type glycerophospholipase activity of PLA2G6 [mitochondrial inner membrane]EC 3.1.1.4; UniProt O60733
Literature
- Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity J Biol Chem, 1998
- Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1 J Biol Chem, 1999
- The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene Eur J Biochem, 1999