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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

1-acyl LPA is acylated to PA by AGPAT5 (OM)

1-acyl LPA + acyl-CoA → PA + CoA-SH

Reactome: R-HSA-1482548
Compartment: mitochondrial outer membrane · cytosol
Rhea: None recorded

Inputs

1-acyl LPACHEBI:16975, C4H8O7PR, mitochondrial outer membrane
acyl-CoACHEBI:58342, C22H31N7O17P3SR, cytosol

Outputs

PACHEBI:57739, C5H5O8PR2, mitochondrial outer membrane
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Catalysed by

1-acylglycerol-3-phosphate O-acyltransferase activity of AGPAT5 [mitochondrial outer membrane]EC 2.3.1.51; UniProt Q9NUQ2

Literature

Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria J Lipid Res, 2011