Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

G3P is acylated to 1-acyl LPA by AGPAT6

G3P + acyl-CoA → 1-acyl LPA + CoA-SH

Reactome: R-HSA-549112
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:15326

Inputs

G3PCHEBI:57597, C3H7O6P, cytosol
acyl-CoACHEBI:58342, C22H31N7O17P3SR, cytosol

Outputs

1-acyl LPACHEBI:16975, C4H8O7PR, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Catalysed by

glycerol-3-phosphate O-acyltransferase activity of AGPAT6 [endoplasmic reticulum membrane]EC 2.3.1.15; UniProt Q86UL3

Literature

Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis Proc Natl Acad Sci U S A, 2006
AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase J Biol Chem, 2008
Acyl-CoA:lysophospholipid acyltransferases J Biol Chem, 2009