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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GDPD5 hydrolyzes GPCho

GPCho + H2O → Cho + G3P

Reactome: R-HSA-6814132
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:16062

Inputs

GPChoCHEBI:16870, C8H20NO6P, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

ChoCHEBI:15354, C5H14NO, cytosol
G3PCHEBI:57597, C3H7O6P, cytosol

Catalysed by

glycerophosphocholine phosphodiesterase activity of GDPD5 [endoplasmic reticulum membrane]EC 3.1.4.2; UniProt Q8WTR4

Literature

GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC Proc. Natl. Acad. Sci. U.S.A., 2008