PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane

PI3P + H2O → PI + Pi

Reactome

R-HSA-1675994

Compartment

plasma membrane · cytosol

Rhea

RHEA:12316

Catalysed by

• phosphatidylinositol-3-phosphate phosphatase activity of MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol]EC 3.1.3.64

Literature

1. Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes Traffic, 2007
2. Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells J Biol Chem, 2004
3. Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases Curr Biol, 2003
4. The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles J Cell Sci, 2002
5. Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease J Biol Chem, 2002
6. FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate Exp Cell Res, 2001