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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PC is hydrolyzed to 1-acyl LPC by PLA2[6]

PC + H2O → 1-acyl LPC + LCFA(-)

Reactome: R-HSA-1482816
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

PCCHEBI:57643, C10H18NO8PR2, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

1-acyl LPCCHEBI:17504, C9H20NO7PR, endoplasmic reticulum membrane
LCFA(-)CHEBI:57560, CO2R, endoplasmic reticulum membrane

Catalysed by

A2-type glycerophospholipase activity of PLA2(6) [endoplasmic reticulum membrane]EC 3.1.1.4

Literature

Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid J Biol Chem, 1989
Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 J Biol Chem, 2002
Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms J Biol Chem, 2010
A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2 J Biol Chem, 1998
Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2 J Biol Chem, 1999
Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma) Biochim Biophys Acta, 2009