PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane
PI(3,5)P2 + H2O → PI5P + Pi
- Reactome
- R-HSA-1676203
- Compartment
- plasma membrane · cytosol
- Rhea
- RHEA:39019
Inputs
- PI(3,5)P2CHEBI:57923, C11H14O19P3R2, plasma membrane
- H2OCHEBI:15377, H2O, cytosol
Outputs
- PI5PCHEBI:57795, C11H15O16P2R2, plasma membrane
- PiCHEBI:43474, HO4P, cytosol
Catalysed by
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol]EC 3.1.3.95
Literature
- SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases J Biol Chem, 1999
- Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes Traffic, 2007
- Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells J Biol Chem, 2004
- Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases Curr Biol, 2003
- The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles J Cell Sci, 2002
- Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity Curr Biol, 2001