PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI(3,4)P2 + H2O → PI4P + Pi
- Reactome
- R-HSA-1676149
- Compartment
- plasma membrane · cytosol
- Rhea
- None recorded
Inputs
- PI(3,4)P2CHEBI:16152, C11H19O19P3R2, plasma membrane
- H2OCHEBI:15377, H2O, cytosol
Outputs
- PI4PCHEBI:17526, C11H18O16P2R2, plasma membrane
- PiCHEBI:43474, HO4P, cytosol
Catalysed by
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol]UniProt P60484
Literature
- The lipid phosphatase activity of PTEN is critical for its tumor supressor function Proc Natl Acad Sci U S A, 1998
- Membrane-binding and activation mechanism of PTEN Proc Natl Acad Sci U S A, 2003
- Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association Cell, 1999
- Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus Eur. J. Biochem., 1996