Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus

PI5P + ATP → ADP + PI(4,5)P2

Reactome: R-HSA-6811522
Compartment: nucleoplasm
Rhea: RHEA:12281

Inputs

PI5PCHEBI:57795, C11H15O16P2R2, nucleoplasm
ATPCHEBI:30616, C10H12N5O13P3, nucleoplasm

Outputs

ADPCHEBI:456216, C10H12N5O10P2, nucleoplasm
PI(4,5)P2CHEBI:58456, C11H14O19P3R2, nucleoplasm

Catalysed by

1-phosphatidylinositol-5-phosphate 4-kinase activity of PIP4K2 dimers [nucleoplasm]EC 2.7.1.149

PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus

Inputs

Outputs

Catalysed by

Literature