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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PE is hydrolyzed to 2-acyl LPE by PLA2[4]

PE + H2O → 2-acyl LPE + LCFA(-)

Reactome: R-HSA-1482828
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

PECHEBI:57613, C7H12NO8PR2, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

2-acyl LPECHEBI:28936, C6H13NO7PR, endoplasmic reticulum membrane
LCFA(-)CHEBI:57560, CO2R, endoplasmic reticulum membrane

Catalysed by

glycerophospholipid phospholipase A1 activity of PLA2(4) [cytosol]EC 3.1.1.32

Literature

Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms J Biol Chem, 2010