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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane

PI(3,5)P2 + H2O → PI5P + Pi

Reactome: R-HSA-6809320
Compartment: plasma membrane · cytosol
Rhea: RHEA:39019

Inputs

PI(3,5)P2CHEBI:57923, C11H14O19P3R2, plasma membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

PI5PCHEBI:57795, C11H15O16P2R2, plasma membrane
PiCHEBI:43474, HO4P, cytosol

Catalysed by

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTMR6:MTMR9,MTMR8:MTMR9 [cytosol]EC 3.1.3.95

Literature

Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8 Proc. Natl. Acad. Sci. U.S.A., 2012
MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis J. Biol. Chem., 2009