PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane

H2O + PI3P → PI + Pi

Reactome

R-HSA-1676141

Compartment

early endosome membrane · cytosol

Rhea

RHEA:12316

Catalysed by

• phosphatidylinositol-3-phosphate phosphatase activity of MTM1,MTMR2,MTMR4 [cytosol]EC 3.1.3.64

Literature

1. FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate Exp Cell Res, 2001
2. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions J Cell Sci, 2006
3. Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes Traffic, 2007
4. Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking Mol Biol Cell, 2008
5. Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease J Biol Chem, 2002