Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane

H2O + PI(3,5)P2 → PI3P + Pi

Reactome: R-HSA-1676020
Compartment: late endosome membrane · cytosol
Rhea: RHEA:32955

Inputs

H2OCHEBI:15377, H2O, cytosol
PI(3,5)P2CHEBI:57923, C11H14O19P3R2, late endosome membrane

Outputs

PI3PCHEBI:58088, C11H15O16P2R2, late endosome membrane
PiCHEBI:43474, HO4P, cytosol

Catalysed by

phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity of PIKFYVE:VAC14:FIG4 [late endosome membrane]EC 3.1.3

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane

Inputs

Outputs

Catalysed by

Literature