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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome

PI(3,5)P2 → PI(3,5)P2

Reactome: R-HSA-1676041
Compartment: early endosome membrane · late endosome membrane
Rhea: None recorded

Inputs

PI(3,5)P2CHEBI:57923, C11H14O19P3R2, early endosome membrane

Outputs

PI(3,5)P2CHEBI:57923, C11H14O19P3R2, late endosome membrane

Literature

Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1 Gene, 2006
Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion Am J Physiol Cell Physiol, 2006
Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve J Biol Chem, 2001