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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PS is hydrolyzed to 1-acyl LPS by PLA2G2A

PS + H2O → 1-acyl LPS + LCFA(-)

Reactome: R-HSA-1482776
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

PSCHEBI:11750, C8H12NO10PR2, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

1-acyl LPSCHEBI:52603, C7H13NO9PR, endoplasmic reticulum membrane
LCFA(-)CHEBI:57560, CO2R, endoplasmic reticulum membrane

Catalysed by

A2-type glycerophospholipase activity of PLA2G2A:Ca2+ [endoplasmic reticulum membrane]EC 3.1.1.4

Literature

Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 J Biol Chem, 2002