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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PTPMT1 dephosphorylates PGP to PG

H2O + PGP → PG + Pi

Reactome: R-HSA-1483197
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: RHEA:33751

Inputs

H2OCHEBI:15377, H2O, mitochondrial matrix
PGPCHEBI:60110, C8H11O13P2R2, mitochondrial inner membrane

Outputs

PGCHEBI:64716, C8H12O10PR2, mitochondrial inner membrane
PiCHEBI:43474, HO4P, mitochondrial matrix

Catalysed by

phosphatidylglycerophosphatase activity of PTPMT1 [mitochondrial inner membrane]EC 3.1.3.27; UniProt Q8WUK0

Literature

Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis Cell Metab., 2011