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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PC is hydrolyzed to 1-acyl LPC by PLB1

PC + H2O → 1-acyl LPC + LCFA(-)

Reactome: R-HSA-1602399
Compartment: extracellular region · plasma membrane
Rhea: None recorded

Inputs

PCCHEBI:57643, C10H18NO8PR2, plasma membrane
H2OCHEBI:15377, H2O, extracellular region

Outputs

1-acyl LPCCHEBI:17504, C9H20NO7PR, plasma membrane
LCFA(-)CHEBI:57560, CO2R, plasma membrane

Catalysed by

A2-type glycerophospholipase activity of PLB1 [plasma membrane]EC 3.1.1.4; UniProt Q6P1J6

Literature

Human epidermis is a novel site of phospholipase B expression Biochem Biophys Res Commun, 2002
Substrate specificity of phospholipase B from guinea pig intestine. A glycerol ester lipase with broad specificity J Biol Chem, 1992