PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane

PI(3,4)P2 + ATP → PI(3,4,5)P3 + ADP

Reactome

R-HSA-1675773

Compartment

plasma membrane · cytosol

Rhea

None recorded

Catalysed by

• phosphatidylinositol kinase activity of PIP5K1A-C [cytosol]

Literature

1. Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules J Biol Chem, 1997
2. Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate J Biol Chem, 1998
3. PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse Neuron, 2001
4. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin Nature, 2002
5. ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma J Cell Biol, 2003