PNPLA6 hydrolyzes LysoPtdCho
LysoPtdCho + H2O → GPCho + LCFA(-)
- Reactome
- R-HSA-6814254
- Compartment
- endoplasmic reticulum membrane · cytosol
- Rhea
- None recorded
Inputs
- LysoPtdChoCHEBI:58168, C9H19NO7PR, endoplasmic reticulum membrane
- H2OCHEBI:15377, H2O, cytosol
Outputs
- GPChoCHEBI:16870, C8H20NO6P, cytosol
- LCFA(-)CHEBI:57560, CO2R, endoplasmic reticulum membrane
Catalysed by
- phosphatidylcholine lysophospholipase A1 activity of PNPLA6 [endoplasmic reticulum membrane]EC 3.1.1.5; UniProt Q8IY17
Literature
- Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl Proc. Natl. Acad. Sci. U.S.A., 2006
- Protein domains, catalytic activity, and subcellular distribution of neuropathy target esterase in Mammalian cells J. Biol. Chem., 2003
- Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells J. Biol. Chem., 2004