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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PNPLA7 hydrolyzes LysoPtdCho

LysoPtdCho + H2O → GPCho + LCFA(-)

Reactome: R-HSA-8847912
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

LysoPtdChoCHEBI:58168, C9H19NO7PR, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

GPChoCHEBI:16870, C8H20NO6P, cytosol
LCFA(-)CHEBI:57560, CO2R, endoplasmic reticulum membrane

Catalysed by

phosphatidylcholine lysophospholipase A1 activity of PNPLA7 [endoplasmic reticulum membrane]EC 3.1.1.5; UniProt Q6ZV29

Literature

Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase J. Biol. Chem., 2008
Characterization of the human patatin-like phospholipase family J. Lipid Res., 2006