PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
PI(4,5)P2 + H2O → PI4P + Pi
- Reactome
- R-HSA-1676177
- Compartment
- plasma membrane · cytosol
- Rhea
- RHEA:22764
Inputs
- PI(4,5)P2CHEBI:58456, C11H14O19P3R2, plasma membrane
- H2OCHEBI:15377, H2O, cytosol
Outputs
- PI4PCHEBI:17526, C11H18O16P2R2, plasma membrane
- PiCHEBI:43474, HO4P, cytosol
Catalysed by
- phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity of SYNJ/INPP5(1) [cytosol]EC 3.1.3.36
Literature
- Identification and characterization of a novel inositol polyphosphate 5-phosphatase J Biol Chem, 2000
- Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation J Biol Chem, 2003
- Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles J Biol Chem, 1999
- The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals Neuron, 2007
- SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases J Biol Chem, 1999
- InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1 Biochem J, 2004