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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane

PI4P + ATP → PI(3,4)P2 + ADP

Reactome: R-HSA-1676109
Compartment: plasma membrane · cytosol
Rhea: None recorded

Inputs

PI4PCHEBI:17526, C11H18O16P2R2, plasma membrane
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

PI(3,4)P2CHEBI:16152, C11H19O19P3R2, plasma membrane
ADPCHEBI:456216, C10H12N5O10P2, cytosol

Catalysed by

1-phosphatidylinositol-4-phosphate 3-kinase activity of PIK3(2) [cytosol]EC 2.7.1.154

Literature

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase Science, 1995
p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma Curr Biol, 2005
Phosphatidylinositol 3-kinase in bovine photoreceptor rod outer segments Invest Ophthalmol Vis Sci, 1997
Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms Protein Expr Purif, 2004
Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain Biochem Biophys Res Commun, 1998
A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration J Biol Chem, 1998