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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane

PS + PI4P → PS + PI4P

Reactome: R-HSA-8867876
Compartment: endoplasmic reticulum membrane · plasma membrane · cytosol
Rhea: RHEA:81667

Inputs

PSCHEBI:11750, C8H12NO10PR2, endoplasmic reticulum membrane
PI4PCHEBI:17526, C11H18O16P2R2, plasma membrane

Outputs

PSCHEBI:11750, C8H12NO10PR2, plasma membrane
PI4PCHEBI:17526, C11H18O16P2R2, endoplasmic reticulum membrane

Catalysed by

phospholipid transfer activity of OSBPL5,8,10 [cytosol]

Literature

Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins Nature, 2013
ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion Biochim. Biophys. Acta, 2012
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism J. Mol. Med., 2009
INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts Science, 2015
A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking J. Cell Biol., 2011