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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MLCL is acylated to CL by HADH (IM)

MLCL + acyl-CoA → cardiolipin + CoA-SH

Reactome: R-HSA-1482775
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: None recorded

Inputs

MLCLCHEBI:60430, C12H19O16P2R3, mitochondrial inner membrane
acyl-CoACHEBI:58342, C22H31N7O17P3SR, mitochondrial matrix

Outputs

cardiolipinCHEBI:28494, C13H18O17P2R4, mitochondrial inner membrane
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Catalysed by

acyltransferase activity, transferring groups other than amino-acyl groups of HADH octamer [mitochondrial inner membrane]EC 2.3.1

Literature

Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1) J Biol Chem, 2009