CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
cardiolipin + 1-acyl LPE → MLCL + PE
- Reactome
- R-HSA-1482894
- Compartment
- mitochondrial inner membrane
- Rhea
- None recorded
Inputs
- cardiolipinCHEBI:28494, C13H18O17P2R4, mitochondrial inner membrane
- 1-acyl LPECHEBI:29017, C6H13NO7PR, mitochondrial inner membrane
Outputs
- MLCLCHEBI:60430, C12H19O16P2R3, mitochondrial inner membrane
- PECHEBI:57613, C7H12NO8PR2, mitochondrial inner membrane
Catalysed by
- 1-acylglycerol-3-phosphate O-acyltransferase activity of TAZ [mitochondrial inner membrane]EC 2.3.1.51; UniProt Q16635
Literature
- Remodeling of cardiolipin by phospholipid transacylation J Biol Chem, 2003
- The enzymatic function of tafazzin J Biol Chem, 2006
- Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species Biochim Biophys Acta, 2009