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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GDE1 hydrolyzes GroPIns

GroPIns + H2O → G3P + Ins

Reactome: R-HSA-6813740
Compartment: plasma membrane · cytosol
Rhea: RHEA:16502

Inputs

GroPInsCHEBI:58444, C9H18O11P, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

G3PCHEBI:57597, C3H7O6P, cytosol
InsCHEBI:17268, C6H12O6, cytosol

Catalysed by

glycerophosphoinositol glycerophosphodiesterase activity of GDE1 [plasma membrane]EC 3.1.4.44; UniProt Q9NZC3

Literature

Genomic organization, characterization, and molecular 3D model of GDE1, a novel mammalian glycerophosphoinositol phosphodiesterase Gene, 2006
MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16 Proc. Natl. Acad. Sci. U.S.A., 2000
GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors Proc. Natl. Acad. Sci. U.S.A., 2003