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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

2-acyl LPE is hydrolyzed to GPETA by PLA2G4C

2-acyl LPE + H2O → GPETA + LCFA(-)

Reactome: R-HSA-1482545
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

2-acyl LPECHEBI:28936, C6H13NO7PR, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

GPETACHEBI:16929, C5H14NO6P, cytosol
LCFA(-)CHEBI:57560, CO2R, endoplasmic reticulum membrane

Catalysed by

phosphatidylcholine lysophospholipase A1 activity of PLA2G4C [endoplasmic reticulum membrane]EC 3.1.1.5; UniProt Q9UP65

Literature

Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma) Biochim Biophys Acta, 2009
Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma) J Biochem, 2005