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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI4P is dephosphorylated to PI by SACM1L at the ER membrane

PI4P + H2O → PI + Pi

Reactome: R-HSA-1676124
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:55652

Inputs

PI4PCHEBI:17526, C11H18O16P2R2, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

PICHEBI:57880, C11H16O13PR2, endoplasmic reticulum membrane
PiCHEBI:43474, HO4P, cytosol

Catalysed by

phosphatidylinositol phosphate 4-phosphatase activity of SACM1L [endoplasmic reticulum membrane]UniProt Q9NTJ5

Literature

The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex J Biol Chem, 2003