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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DLCL is acylated to MLCL by LCLAT1 (ER)

DLCL + acyl-CoA → MLCL + CoA-SH

Reactome: R-HSA-1482867
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

DLCLCHEBI:75137, C11H18O15P2R2, endoplasmic reticulum membrane
acyl-CoACHEBI:58342, C22H31N7O17P3SR, cytosol

Outputs

MLCLCHEBI:60430, C12H19O16P2R3, endoplasmic reticulum membrane
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Catalysed by

acyltransferase activity, transferring groups other than amino-acyl groups of LCLAT1 [endoplasmic reticulum membrane]EC 2.3.1; UniProt Q6UWP7

Literature

The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids J Lipid Res, 2009