PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane

PI3P + ATP → PI(3,4)P2 + ADP

Reactome

R-HSA-1676145

Compartment

plasma membrane · cytosol

Rhea

None recorded

Catalysed by

• 1-phosphatidylinositol-3-phosphate 4-kinase activity of PIP4K2/5K1 [cytosol]EC 2.7.1

Literature

1. Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases Adv Enzyme Regul, 2010
2. Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules J Biol Chem, 1997
3. A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Nature, 1997
4. Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate J Biol Chem, 1998
5. Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron Am J Physiol Renal Physiol, 2008
6. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin Nature, 2002