CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane

DAG + CDP-Cho → PC + CMP

Reactome

R-HSA-1482961

Compartment

endoplasmic reticulum membrane · cytosol

Rhea

RHEA:32939

Catalysed by

• diacylglycerol cholinephosphotransferase activity of CEPT1:Mg2+/Mn2+ [endoplasmic reticulum membrane]EC 2.7.8.2

Literature

1. Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine Biochem J, 1999
2. Cloning, genomic organization, and characterization of a human cholinephosphotransferase J Biol Chem, 2000
3. PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1) Lipids, 2002
4. The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity Mol Biol Cell, 2002