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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DHAP is converted to G3P by GPD1/GPD1L

DHAP + NADH + H+ → G3P + NAD+

Reactome: R-HSA-75889
Compartment: cytosol
Rhea: RHEA:11094

Inputs

DHAPCHEBI:57642, C3H5O6P, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol
H+CHEBI:15378, H, cytosol

Outputs

G3PCHEBI:57597, C3H7O6P, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Catalysed by

glycerol-3-phosphate dehydrogenase [NAD(P)+] activity of GPD1/GPD1L homodimer [cytosol]EC 1.1.1.94

Literature

GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A Am J Physiol Heart Circ Physiol, 2009
Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1) J Mol Biol, 2006