Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PG and CDP-DAG are converted to CL by CRLS1

PG + CDP-DAG → cardiolipin + CMP

Reactome: R-HSA-1483063
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: RHEA:32931

Inputs

PGCHEBI:64716, C8H12O10PR2, mitochondrial inner membrane
CDP-DAGCHEBI:58332, C14H17N3O15P2R2, mitochondrial inner membrane

Outputs

cardiolipinCHEBI:28494, C13H18O17P2R4, mitochondrial inner membrane
CMPCHEBI:60377, C9H12N3O8P, mitochondrial matrix

Catalysed by

cardiolipin synthase (CMP-forming) activity of CRLS1 [mitochondrial inner membrane]EC 2.7.8.41; UniProt Q9UJA2

Literature

Identification and characterization of human cardiolipin synthase FEBS Lett, 2006
Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1) J Lipid Res, 2006