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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SBF1 binds MTMR2

MTMR2 + SBF1 → MTMR2:SBF1

Reactome: R-HSA-6809764
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

MTMR2R-HSA-1604662, cytosol
SBF1R-HSA-6809747, endoplasmic reticulum membrane

Outputs

MTMR2:SBF1R-HSA-6809761, endoplasmic reticulum membrane

Catalysed by

protein-membrane adaptor activity of SBF1 [endoplasmic reticulum membrane]UniProt O95248

Literature

Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module Proc. Natl. Acad. Sci. U.S.A., 2003
Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase Proc. Natl. Acad. Sci. U.S.A., 2003
SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2 Cell Death Dis, 2014