Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI3P is dephosphorylated to PI by MTM1:MTMR12

H2O + PI3P → PI + Pi

Reactome: R-HSA-6809720
Compartment: early endosome membrane · cytosol
Rhea: RHEA:12316

Inputs

H2OCHEBI:15377, H2O, cytosol
PI3PCHEBI:58088, C11H15O16P2R2, early endosome membrane

Outputs

PICHEBI:57880, C11H16O13PR2, early endosome membrane
PiCHEBI:43474, HO4P, cytosol

Catalysed by

phosphatidylinositol-3-phosphate phosphatase activity of MTM1:MTMR12 [cytosol]EC 3.1.3.64

Literature

Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate J. Biol. Chem., 1991
Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP Proc. Natl. Acad. Sci. U.S.A., 2003
Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish PLoS Genet., 2013