Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

2-acyl LPG is acylated to PG by CRLS1 (IM)

2-acyl LPG + acyl-CoA → PG + CoA-SH

Reactome: R-HSA-1482546
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: None recorded

Inputs

2-acyl LPGCHEBI:27923, C7H14O9PR, mitochondrial inner membrane
acyl-CoACHEBI:58342, C22H31N7O17P3SR, mitochondrial matrix

Outputs

PGCHEBI:64716, C8H12O10PR2, mitochondrial inner membrane
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Catalysed by

2-acylglycerol-3-phosphate O-acyltransferase activity of CRLS1 [mitochondrial inner membrane]EC 2.3.1.52; UniProt Q9UJA2

Literature

A novel function of the human CLS1 in phosphatidylglycerol synthesis and remodeling Biochim Biophys Acta, 2010