PGP:Mg2+ dimer hydrolyses G3P to glycerol
H2O + G3P → Glycerol + Pi
- Reactome
- R-HSA-8955794
- Compartment
- cytosol
- Rhea
- RHEA:66373
Inputs
- H2OCHEBI:15377, H2O, cytosol
- G3PCHEBI:57597, C3H7O6P, cytosol
Outputs
- GlycerolCHEBI:17754, C3H8O3, cytosol
- PiCHEBI:43474, HO4P, cytosol
Catalysed by
- sn-glycerol 3-phosphatase activity of PGP:Mg2+ dimer [cytosol]EC 3.1.3.21
Literature
- Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress Mol Metab, 2022
- Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia Mol Metab, 2022
- Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes Proc. Natl. Acad. Sci. U.S.A., 2016
- Essential role of germ cell glycerol-3-phosphate phosphatase for sperm health, oxidative stress control and male fertility in mice Mol Metab, 2024
- Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities J Biol Chem, 2014