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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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PGP:Mg2+ dimer hydrolyses G3P to glycerol

H2O + G3P → Glycerol + Pi

Reactome
R-HSA-8955794
Compartment
cytosol
Rhea
RHEA:66373

Inputs

Outputs

Catalysed by

  • sn-glycerol 3-phosphatase activity of PGP:Mg2+ dimer [cytosol]EC 3.1.3.21

Literature

  1. Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress Mol Metab, 2022
  2. Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia Mol Metab, 2022
  3. Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes Proc. Natl. Acad. Sci. U.S.A., 2016
  4. Essential role of germ cell glycerol-3-phosphate phosphatase for sperm health, oxidative stress control and male fertility in mice Mol Metab, 2024
  5. Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities J Biol Chem, 2014