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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PS is decarboxylated to PE by PISD

PS → PE + CO2

Reactome: R-HSA-1483212
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: None recorded

Inputs

PSCHEBI:11750, C8H12NO10PR2, mitochondrial inner membrane

Outputs

PECHEBI:57613, C7H12NO8PR2, mitochondrial inner membrane
CO2CHEBI:16526, CO2, mitochondrial matrix

Catalysed by

phosphatidylserine decarboxylase activity of PISD:Pyruvoyl [mitochondrial inner membrane]EC 4.1.1.65

Literature

High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase J Biomol Screen, 2007