PC is exchanged with PI by PITPNB

PC:PITPNB + PI → PI:PITPNB + PC

Reactome

R-HSA-1483219

Compartment

endoplasmic reticulum membrane

Rhea

None recorded

Catalysed by

• phosphatidylcholine transfer activity of PC:PITPNB [endoplasmic reticulum membrane]

Literature

1. Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells Traffic, 2008
2. Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum J Cell Sci, 2010
3. Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine J Biol Chem, 2001
4. Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms Biochemistry, 2005
5. Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association EMBO J, 2002
6. Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol Structure, 2004