PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane

H2O + PI3P → PI + Pi

Reactome

R-HSA-1675795

Compartment

late endosome membrane · cytosol

Rhea

RHEA:12316

Catalysed by

• phosphatidylinositol-3-phosphate phosphatase activity of MTM1,MTMR2,MTMR4,MTMR7 [cytosol]EC 3.1.3.64

Literature

1. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions J Cell Sci, 2006
2. Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease J Biol Chem, 2002
3. Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking Mol Biol Cell, 2008
4. Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells J Biol Chem, 2004
5. Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes Traffic, 2007
6. Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction J Biol Chem, 2004