PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane

ATP + PI4P → ADP + PI(3,4)P2

Reactome

R-HSA-1675928

Compartment

Golgi membrane · cytosol

Rhea

None recorded

Catalysed by

• 1-phosphatidylinositol-4-phosphate 3-kinase activity of PIK3C2A/G [cytosol]EC 2.7.1.154

Literature

1. The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles J Biol Chem, 2000
2. A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration J Biol Chem, 1998
3. cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12 Genomics, 1998
4. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors Mol Cell Biol, 2000