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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

1-acyl LPA is acylated to PA by AGPAT (LPAAT)

1-acyl LPA + acyl-CoA → PA + CoA-SH

Reactome: R-HSA-75885
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

1-acyl LPACHEBI:16975, C4H8O7PR, cytosol
acyl-CoACHEBI:58342, C22H31N7O17P3SR, cytosol

Outputs

PACHEBI:57739, C5H5O8PR2, endoplasmic reticulum membrane
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Catalysed by

1-acylglycerol-3-phosphate O-acyltransferase activity of AGPAT [endoplasmic reticulum membrane]EC 2.3.1.51

Literature

Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity Arch Biochem Biophys, 2006
Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex J Biol Chem, 1998
Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart Biochem J, 2005
Acyl-CoA:lysophospholipid acyltransferases J Biol Chem, 2009
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis Am J Physiol Endocrinol Metab, 2009
Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells DNA Cell Biol, 1997