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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane

ATP + PI → ADP + PI5P

Reactome: R-HSA-1675866
Compartment: late endosome membrane · cytosol
Rhea: RHEA:44680

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
PICHEBI:57880, C11H16O13PR2, late endosome membrane

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
PI5PCHEBI:57795, C11H15O16P2R2, late endosome membrane

Catalysed by

1-phosphatidylinositol-5-kinase activity of PIKFYVE:VAC14:FIG4 [late endosome membrane]EC 2.7.1

PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane

Inputs

Outputs

Catalysed by

Literature