DAG is acylated to TAG by DGAT1/2
DAG + acyl-CoA → TAG + CoA-SH
- Reactome
- R-HSA-1482889
- Compartment
- endoplasmic reticulum membrane · cytosol
- Rhea
- None recorded
Inputs
- DAGCHEBI:17815, C5H6O5R2, endoplasmic reticulum membrane
- acyl-CoACHEBI:58342, C22H31N7O17P3SR, cytosol
Outputs
- TAGCHEBI:17855, C6H5O6R3, endoplasmic reticulum membrane
- CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
Catalysed by
- diacylglycerol O-acyltransferase activity of DGAT1/2 [endoplasmic reticulum membrane]EC 2.3.1.20
Literature
- Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes J Biol Chem, 1998
- Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members J Biol Chem, 2001
- A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice Biochem Biophys Res Commun, 2003