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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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PLD6 dimer hydrolyses cardiolipin to PA and PG

cardiolipin + H2O → PA + PG

Reactome
R-HSA-8954398
Compartment
mitochondrial outer membrane · mitochondrial intermembrane space
Rhea
None recorded

Inputs

  • cardiolipinCHEBI:28494, C13H18O17P2R4, mitochondrial outer membrane
  • H2OCHEBI:15377, H2O, mitochondrial intermembrane space

Outputs

  • PACHEBI:57739, C5H5O8PR2, mitochondrial outer membrane
  • PGCHEBI:64716, C8H12O10PR2, mitochondrial outer membrane

Catalysed by

  • cardiolipin phospholipase D activity of PLD6 dimer [mitochondrial outer membrane]

Literature

  1. A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis Nat. Cell Biol., 2006
  2. Phospholipid scramblase 3 controls mitochondrial structure, function, and apoptotic response Mol. Cancer Res., 2003
  3. Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis Mol. Cell, 2016