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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

2-acyl LPC is hydrolyzed to GPCho by PLA2[8]

2-acyl LPC + H2O → GPCho + LCFA(-)

Reactome: R-HSA-1482612
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

2-acyl LPCCHEBI:16728, C9H20NO7PR, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

GPChoCHEBI:16870, C8H20NO6P, cytosol
LCFA(-)CHEBI:57560, CO2R, endoplasmic reticulum membrane

Catalysed by

phosphatidylcholine lysophospholipase A1 activity of PLA2(8) [cytosol]EC 3.1.1.5

Literature

The identification of a phospholipase B precursor in human neutrophils FEBS J, 2009
Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms J Biol Chem, 2010
Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2 J Biol Chem, 1994
Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma) Biochim Biophys Acta, 2009
Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma) J Biochem, 2005