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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane

H2O + PI(3,5)P2 → PI5P + Pi

Reactome: R-HSA-1676065
Compartment: late endosome membrane · cytosol
Rhea: RHEA:39019

Inputs

H2OCHEBI:15377, H2O, cytosol
PI(3,5)P2CHEBI:57923, C11H14O19P3R2, late endosome membrane

Outputs

PI5PCHEBI:57795, C11H15O16P2R2, late endosome membrane
PiCHEBI:43474, HO4P, cytosol

Catalysed by

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTM1,MTMR2,MTMR4,MTMR7 [cytosol]EC 3.1.3.95

Literature

Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions J Cell Sci, 2006
Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction J Biol Chem, 2004
Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells J Biol Chem, 2004
Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes Traffic, 2007
Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking Mol Biol Cell, 2008
Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 Proc Natl Acad Sci U S A, 2003